HOXC13

Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.^[5][6][7]

HOXC13
Identifiers
Aliases	HOXC13, ECTD9, HOX3, HOX3G, homeobox C13
External IDs	OMIM: 142976; MGI: 99560; HomoloGene: 7770; GeneCards: HOXC13; OMA:HOXC13 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,938,831 bp[1] End 53,946,544 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 57.99 cM Start 102,829,538 bp[2] End 102,837,249 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in hair follicle gonad testicle skin of arm skin of leg skin of abdomen placenta popliteal artery tibial arteries female breast Top expressed in lip hair follicle filiform papilla tail of embryo skin of back skin of abdomen genital tubercle blastocyst stroma of bone marrow morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process hair follicle development multicellular organism development nail development regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated anterior/posterior pattern specification tongue morphogenesis positive regulation of transcription by RNA polymerase II anatomical structure morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3229 15422 Ensembl ENSG00000123364 ENSMUSG00000001655 UniProt P31276 P50207 RefSeq (mRNA) NM_017410 NM_010464 RefSeq (protein) NP_059106 NP_034594 Location (UCSC) Chr 12: 53.94 – 53.95 Mb Chr 15: 102.83 – 102.84 Mb PubMed search [3] [4]
Wikidata
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Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla.^[7]

See also

• Homeobox