HOXD9

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.^[5][6][7]

HOXD9
Identifiers
Aliases	HOXD9, HOX4, HOX4C, Hox-4.3, Hox-5.2, homeobox D9
External IDs	OMIM: 142982; MGI: 96210; HomoloGene: 8409; GeneCards: HOXD9; OMA:HOXD9 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 176,122,719 bp[1] End 176,124,937 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C3|2 44.13 cM Start 74,528,071 bp[2] End 74,530,552 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of uterus tendon of biceps brachii canal of the cervix vagina ectocervix myometrium muscle layer of sigmoid colon buccal mucosa cell testicle stromal cell of endometrium Top expressed in Gonadal ridge gastrula decidua medullary collecting duct endothelial cell of lymphatic vessel seminal vesicula medial head of gastrocnemius muscle cumulus cell tail of embryo urothelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleolus Biological process embryonic skeletal system morphogenesis forelimb morphogenesis peripheral nervous system neuron development proximal/distal pattern formation regulation of transcription, DNA-templated adult locomotory behavior negative regulation of transcription by RNA polymerase II hindlimb morphogenesis transcription, DNA-templated single fertilization embryonic skeletal system development mammary gland development multicellular organism development regulation of gene expression skeletal muscle tissue development embryonic forelimb morphogenesis anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3235 15438 Ensembl ENSG00000128709 ENSMUSG00000043342 UniProt P28356 P28357 RefSeq (mRNA) NM_014213 NM_013555 RefSeq (protein) NP_055028 NP_038583 Location (UCSC) Chr 2: 176.12 – 176.12 Mb Chr 2: 74.53 – 74.53 Mb PubMed search [3] [4]
Wikidata
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Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.^[7]

See also

• Homeobox