HP1BP3

Heterochromatin protein 1, binding protein 3 is a protein that in humans is encoded by the HP1BP3 gene.^[5] It has been identified as a novel subtype of the linker histone H1, involved in the structure of heterochromatin ^[6][7][8]

HP1BP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RQP
Identifiers
Aliases	HP1BP3, HP1-BP74, HP1BP74, heterochromatin protein 1 binding protein 3
External IDs	OMIM: 616072; MGI: 109369; HomoloGene: 7774; GeneCards: HP1BP3; OMA:HP1BP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.12 Start 20,742,679 bp[1] End 20,787,323 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 137,943,607 bp[2] End 137,971,994 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 ventricular zone tibia trabecular bone parietal pleura visceral pleura skin of hip Achilles tendon parotid gland seminal vesicula Top expressed in renal corpuscle medullary collecting duct ventricular zone condyle ascending aorta aortic valve neural layer of retina ganglionic eminence vestibular membrane of cochlear duct thymus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleosome binding protein binding chromatin binding Cellular component nucleosome nucleus chromosome nuclear speck Biological process regulation of nucleus size nucleosome assembly heterochromatin organization regulation of transcription, DNA-templated regulation of cell population proliferation cellular response to hypoxia Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50809 15441 Ensembl ENSG00000127483 ENSMUSG00000028759 UniProt Q5SSJ5 Q3TEA8 RefSeq (mRNA) NM_016287 NM_001372052 NM_001122896 NM_001122897 NM_001285478 NM_001285479 NM_001285480 NM_001285481 NM_010470 NM_001356431 NM_001356432 RefSeq (protein) NP_057371 NP_001358981 NP_001363716 NP_001363717 NP_001363718 NP_001363719 NP_001363720 NP_001363721 NP_001363722 NP_001363723 NP_001363724 NP_001363725 NP_001363726 NP_001116368 NP_001116369 NP_001272407 NP_001272408 NP_001272409 NP_001272410 NP_034600 NP_001343360 NP_001343361 Location (UCSC) Chr 1: 20.74 – 20.79 Mb Chr 4: 137.94 – 137.97 Mb PubMed search [3] [4]
Wikidata
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