HPSE2

Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene.^[5][6]

HPSE2
Identifiers
Aliases	HPSE2, HPA2, HPR2, UFS, UFS1, heparanase 2 (inactive)
External IDs	OMIM: 613469; MGI: 2685814; HomoloGene: 19680; GeneCards: HPSE2; OMA:HPSE2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.2 Start 98,457,077 bp[1] End 99,235,862 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 42,774,978 bp[2] End 43,376,794 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon canal of the cervix gastric mucosa ectocervix popliteal artery tibial arteries Hypothalamus caudate nucleus putamen C1 segment Top expressed in genital tubercle pineal gland spermatid zygote migratory enteric neural crest cell hand urinary bladder lobe of prostate lip Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparan sulfate proteoglycan binding heparanase activity hydrolase activity, acting on glycosyl bonds Cellular component extracellular region plasma membrane intracellular anatomical structure membrane extracellular matrix Biological process glycosaminoglycan catabolic process positive regulation of cell population proliferation extracellular matrix organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60495 545291 Ensembl ENSG00000172987 ENSMUSG00000074852 UniProt Q8WWQ2 B2RY83 RefSeq (mRNA) NM_001166244 NM_001166245 NM_001166246 NM_021828 NM_001081257 RefSeq (protein) NP_001159716 NP_001159717 NP_001159718 NP_068600 NP_001074726 Location (UCSC) Chr 10: 98.46 – 99.24 Mb Chr 19: 42.77 – 43.38 Mb PubMed search [3] [4]
Wikidata
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It may be associated with urofacial syndrome.^[7]