HRK (gene)

Activator of apoptosis harakiri is a protein that in humans is encoded by the HRK gene.^[5][6]

HRK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L58, 2L5B
Identifiers
Aliases	HRK, DP5, HARAKIRI, harakiri, BCL2 interacting protein
External IDs	OMIM: 603447; MGI: 1201608; HomoloGene: 136405; GeneCards: HRK; OMA:HRK - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.22 Start 116,856,144 bp[1] End 116,881,441 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 118,302,713 bp[2] End 118,327,543 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell endothelial cell pancreatic ductal cell gonad testicle Brodmann area 23 hippocampus proper prefrontal cortex cingulate gyrus anterior cingulate cortex Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus Rostral migratory stream trigeminal ganglion striatum of neuraxis primary visual cortex temporal lobe nucleus accumbens Region I of hippocampus proper dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane membrane mitochondrion Biological process regulation of apoptotic process positive regulation of protein homooligomerization positive regulation of release of cytochrome c from mitochondria positive regulation of apoptotic process apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8739 12123 Ensembl ENSG00000135116 ENSMUSG00000046607 UniProt O00198 P62816 RefSeq (mRNA) NM_003806 NM_007545 RefSeq (protein) NP_003797 NP_031571 Location (UCSC) Chr 12: 116.86 – 116.88 Mb Chr 5: 118.3 – 118.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.^[6]

Interactions

HRK (gene) has been shown to interact with:

• BCL2-like 1,^[5][7][8] and
• Bcl-2.^[5][9]