HSD17B11

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.^[5][6][7][8]

HSD17B11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YB1
Identifiers
Aliases	HSD17B11, 17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2, hydroxysteroid (17-beta) dehydrogenase 11, hydroxysteroid 17-beta dehydrogenase 11
External IDs	OMIM: 612831; MGI: 2149821; HomoloGene: 69209; GeneCards: HSD17B11; OMA:HSD17B11 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q22.1 Start 87,336,515 bp[1] End 87,391,188 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E5 Start 104,137,628 bp[2] End 104,169,785 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of colon duodenum mucosa of sigmoid colon rectum mucosa of ileum monocyte gallbladder mucosa of transverse colon blood Top expressed in vestibular membrane of cochlear duct pyloric antrum epithelium of stomach mucous cell of stomach iris intestinal villus stria vascularis Ileal epithelium left lobe of liver duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity steroid dehydrogenase activity estradiol 17-beta-dehydrogenase activity Cellular component cytoplasm extracellular region cytosol lipid droplet Biological process estrogen biosynthetic process androgen catabolic process lipid metabolism steroid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51170 114664 Ensembl ENSG00000198189 ENSMUSG00000029311 UniProt Q8NBQ5 Q9EQ06 RefSeq (mRNA) NM_016245 NM_053262 RefSeq (protein) NP_057329 NP_444492 Location (UCSC) Chr 4: 87.34 – 87.39 Mb Chr 5: 104.14 – 104.17 Mb PubMed search [3] [4]
Wikidata
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HSD17B11 expression has been linked to higher survival rates for lung cancer patients.^[9]