HSD17B12

Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.^[5][6][7]

HSD17B12
Identifiers
Aliases	HSD17B12, KAR, SDR12C1, hydroxysteroid (17-beta) dehydrogenase 12, hydroxysteroid 17-beta dehydrogenase 12
External IDs	OMIM: 609574; MGI: 1926967; HomoloGene: 95094; GeneCards: HSD17B12; OMA:HSD17B12 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 43,680,680 bp[1] End 43,856,617 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 93,863,034 bp[2] End 93,988,309 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell retinal pigment epithelium pancreatic ductal cell optic nerve pars reticulata inferior ganglion of vagus nerve cardia renal medulla spinal ganglia pars compacta Top expressed in skin of external ear brown adipose tissue transitional epithelium of urinary bladder cumulus cell tunica adventitia of aorta left lobe of liver ciliary body iris sciatic nerve lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding estradiol 17-beta-dehydrogenase activity oxidoreductase activity collagen binding fibronectin binding protein binding 3-oxo-lignoceroyl-CoA reductase activity 3-oxo-behenoyl-CoA reductase activity long-chain-3-hydroxyacyl-CoA dehydrogenase activity 3-oxo-arachidoyl-CoA reductase activity 3-oxo-cerotoyl-CoA reductase activity Cellular component integral component of membrane membrane endoplasmic reticulum endoplasmic reticulum membrane extracellular matrix Biological process lipid metabolism extracellular matrix organization long-chain fatty-acyl-CoA biosynthetic process positive regulation of cell-substrate adhesion fatty acid biosynthetic process estrogen biosynthetic process steroid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51144 56348 Ensembl ENSG00000149084 ENSMUSG00000027195 UniProt Q53GQ0 O70503 RefSeq (mRNA) NM_016142 NM_019657 RefSeq (protein) NP_057226 NP_062631 Location (UCSC) Chr 11: 43.68 – 43.86 Mb Chr 2: 93.86 – 93.99 Mb PubMed search [3] [4]
Wikidata
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The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12) uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA during the second step of fatty acid elongation.[supplied by OMIM]^[7]