HSD17B13

17β-Hydroxysteroid dehydrogenase type 13 also known as 17β-HSD type 13 is an enzyme that in humans is encoded by the HSD17B13 gene.^[5][6]

HSD17B13
Identifiers
Aliases	HSD17B13, NIIL497, SCDR9, SDR16C3, HMFN0376, hydroxysteroid (17-beta) dehydrogenase 13, hydroxysteroid 17-beta dehydrogenase 13
External IDs	OMIM: 612127; MGI: 2140804; HomoloGene: 71549; GeneCards: HSD17B13; OMA:HSD17B13 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q22.1 Start 87,303,789 bp[1] End 87,322,886 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E5 Start 104,103,306 bp[2] End 104,125,276 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver olfactory zone of nasal mucosa vagina subcutaneous adipose tissue lactiferous gland myometrium ectocervix skin of leg body of uterus Top expressed in left lobe of liver epithelium of small intestine duodenum zygote secondary oocyte ileum migratory enteric neural crest cell primary oocyte islet of Langerhans jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity molecular function steroid dehydrogenase activity Cellular component extracellular region lipid droplet cytosol cellular component Biological process positive regulation of lipid biosynthetic process lipid droplet organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 345275 243168 Ensembl ENSG00000170509 ENSMUSG00000034528 UniProt Q7Z5P4 Q8VCR2 RefSeq (mRNA) NM_178135 NM_001136230 NM_001163486 NM_198030 RefSeq (protein) NP_001129702 NP_835236 NP_001156958 NP_932147 Location (UCSC) Chr 4: 87.3 – 87.32 Mb Chr 5: 104.1 – 104.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

17β-HSD13 is significantly up-regulated in the liver of patients with non-alcoholic fatty liver disease (NAFLD) and enhances lipogenesis.^[7]

Inhibitors

In 2023 the first potent and selective HSD17B13 inhibitor, BI-3231, was reported.^[8] The inhibitor meets the quality criteria of a 'Donated Chemical Probe' as defined by the Structural Genomics Consortium.^[9]