HSD17B14

17β-Hydroxysteroid dehydrogenase type 14 also known as 17β-HSD type 14 or 17βHSD14 is an enzyme that in humans is encoded by the HSD17B14 gene.^[5][6]

HSD17B14
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1YDE, 5ICS, 5ICM, 5JS6, 5HS6, 5JSF
Identifiers
Aliases	HSD17B14, DHRS10, SDR47C1, retSDR3, hydroxysteroid (17-beta) dehydrogenase 14, hydroxysteroid 17-beta dehydrogenase 14
External IDs	OMIM: 612832; MGI: 1913315; HomoloGene: 133800; GeneCards: HSD17B14; OMA:HSD17B14 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,813,018 bp[1] End 48,836,510 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,204,317 bp[2] End 45,217,176 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa right adrenal cortex right lobe of liver left ovary left adrenal cortex nucleus accumbens testicle right ovary right hemisphere of cerebellum caudate nucleus Top expressed in morula blastocyst lip transitional epithelium of urinary bladder embryo muscle of thigh esophagus gastrula blood right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity protein binding testosterone 17-beta-dehydrogenase (NADP+) activity identical protein binding estradiol 17-beta-dehydrogenase activity Cellular component cytoplasm cytosol Biological process steroid metabolic process steroid catabolic process lipid metabolism estrogen biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51171 66065 Ensembl ENSG00000087076 ENSMUSG00000030825 UniProt Q9BPX1 n/a RefSeq (mRNA) NM_016246 NM_025330 RefSeq (protein) NP_057330 n/a Location (UCSC) Chr 19: 48.81 – 48.84 Mb Chr 7: 45.2 – 45.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

17βHSD14 catalyzes the stereospecific oxidation and reduction of the 17β carbon atom of androgens and estrogens using NAD(P)(H) as a cofactor. It is primarily expressed in glandular epithelial tissues of breast, ovary, and testis.^[7]