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HSD17B2
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
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17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in humans is encoded by the HSD17B2 gene.[5][6][7]
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Function
17β-HSD2 is involved in inactivation of androgens and estrogens,[8] being accurately describable as "antiandrogenic" and "antiestrogenic",[9] and is the key 17β-HSD isozyme in androgen and estrogen inactivation.[8][additional citation(s) needed] Specific reactions catalyzed by 17β-HSD2 include estradiol to estrone, testosterone to androstenedione, and androstenediol to DHEA.[8][10] In addition to 17β-HSD activity, this enzyme also shows high 20α-hydroxysteroid dehydrogenase activity and can activate the weak progestogen 20α-hydroxyprogesterone into the potent progestogen progesterone.[8][10]
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Expression
17β-HSD2 is widely expressed throughout the body including in the placenta, liver, intestines, endometrium, kidney, pancreas, breast, prostate, bone, and many other tissues.[11][12]
Clinical significance
Polymorphisms in HSD17B2 have been associated with breast cancer and prostate cancer.[13] 17β-HSD2 activity has also been associated with endometriosis and osteoporosis,[14] and inhibitors of the enzyme are of potential interest in the treatment of the latter condition.[15][16] Inactivating mutations resulting in a syndrome of congenital deficiency of 17β-HSD2 have not been reported to date.[17]
References
Further reading
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