HSD17B6

Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene.^[5][6][7]

HSD17B6
Identifiers
Aliases	HSD17B6, HSE, RODH, SDR9C6, hydroxysteroid (17-beta) dehydrogenase 6, hydroxysteroid 17-beta dehydrogenase 6
External IDs	OMIM: 606623; MGI: 1351670; HomoloGene: 20811; GeneCards: HSD17B6; OMA:HSD17B6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,752,161 bp[1] End 56,787,790 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,826,805 bp[2] End 127,843,480 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver lower lobe of lung seminal vesicula parietal pleura spleen canal of the cervix saphenous vein caudate nucleus nucleus accumbens prostate Top expressed in left lobe of liver duodenum olfactory epithelium jejunum morula intestinal villus pyloric antrum blastocyst epithelium of stomach mucous cell of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function electron transfer activity oxidoreductase activity estradiol 17-beta-dehydrogenase activity catalytic activity testosterone dehydrogenase (NAD+) activity NAD-retinol dehydrogenase activity Cellular component organelle membrane endosome early endosome membrane intracellular anatomical structure endoplasmic reticulum membrane intracellular membrane-bounded organelle Biological process androgen biosynthetic process androgen catabolic process steroid metabolic process lipid metabolism electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8630 27400 Ensembl ENSG00000025423 ENSMUSG00000025396 UniProt O14756 Q9R092 RefSeq (mRNA) NM_003725 NM_013786 NM_001359377 RefSeq (protein) NP_003716 NP_038814 NP_001346306 Location (UCSC) Chr 12: 56.75 – 56.79 Mb Chr 10: 127.83 – 127.84 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.^[7]