HSF2

Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.^[5][6]

HSF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5D8K, 5D8L
Identifiers
Aliases	HSF2, HSF 2, HSTF 2, heat shock transcription factor 2
External IDs	OMIM: 140581; MGI: 96239; HomoloGene: 37931; GeneCards: HSF2; OMA:HSF2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.31 Start 122,399,551 bp[1] End 122,433,119 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 57,362,481 bp[2] End 57,389,231 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle Skeletal muscle tissue of biceps brachii muscle of leg gastrocnemius muscle muscle of thigh ganglionic eminence gonad Skeletal muscle tissue of rectus abdominis Achilles tendon bronchial epithelial cell Top expressed in spermatid genital tubercle tail of embryo ventricular zone muscle of thigh neural layer of retina morula spermatocyte embryo superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding DNA-binding transcription factor activity RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding protein homodimerization activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription coactivator activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cytoplasm nucleoplasm Biological process regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II spermatogenesis regulation of transcription by RNA polymerase II transcription, DNA-templated cellular response to heat positive regulation of transcription from RNA polymerase II promoter in response to heat stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3298 15500 Ensembl ENSG00000025156 ENSMUSG00000019878 UniProt Q03933 Q9BS48 P38533 RefSeq (mRNA) NM_004506 NM_001135564 NM_001243094 NM_008297 RefSeq (protein) NP_001129036 NP_001230023 NP_004497 NP_001230023.1 NP_032323 Location (UCSC) Chr 6: 122.4 – 122.43 Mb Chr 10: 57.36 – 57.39 Mb PubMed search [3] [4]
Wikidata
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Function

HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.^[6]

Interactions

HSF2 has been shown to interact with Nucleoporin 62^[7] and HSF1.^[8]

See also

• Heat shock factor