HSF4

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.^[5][6][7][8]

HSF4
Identifiers
Aliases	HSF4, CTM, CTRCT5, heat shock transcription factor 4
External IDs	OMIM: 602438; MGI: 1347058; HomoloGene: 100128; GeneCards: HSF4; OMA:HSF4 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,164,681 bp[1] End 67,169,945 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 105,996,433 bp[2] End 106,002,477 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary gastric mucosa right uterine tube body of pancreas apex of heart canal of the cervix right ovary left uterine tube right frontal lobe Top expressed in lens muscle of thigh female urethra superior frontal gyrus primary visual cortex cerebellar cortex central gray substance of midbrain dentate gyrus of hippocampal formation granule cell epithelium of lens lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding transcription corepressor activity DNA-binding transcription factor activity protein phosphatase binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus nuclear speck Biological process eye development regulation of transcription, DNA-templated cell development histone H3-K9 demethylation negative regulation of transcription by RNA polymerase II transcription, DNA-templated protein homotrimerization positive regulation of cell differentiation positive regulation of cell population proliferation camera-type eye development negative regulation of transcription, DNA-templated protein homooligomerization positive regulation of transcription by RNA polymerase II visual perception cellular response to heat positive regulation of transcription from RNA polymerase II promoter in response to heat stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3299 26386 Ensembl ENSG00000102878 ENSMUSG00000033249 UniProt Q9ULV5 Q9R0L1 RefSeq (mRNA) NM_001538 NM_001040667 NM_001374674 NM_001374675 NM_001256042 NM_001256044 NM_011939 RefSeq (protein) NP_001035757 NP_001529 NP_001361603 NP_001361604 NP_001242971 NP_001242973 NP_036069 Location (UCSC) Chr 16: 67.16 – 67.17 Mb Chr 8: 106 – 106 Mb PubMed search [3] [4]
Wikidata
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Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.^[8]

See also

• Heat shock factor