HSPA2

Heat shock-related 70 kDa protein 2 is a protein that in humans is encoded by the HSPA2 gene.^[5]

HSPA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3I33, 4FSV, 5FPM, 5FPN, 5FPD, 5FPE
Identifiers
Aliases	HSPA2, HSP70-2, HSP70-3, heat shock protein family A (Hsp70) member 2
External IDs	OMIM: 140560; MGI: 96243; HomoloGene: 68564; GeneCards: HSPA2; OMA:HSPA2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.3 Start 64,535,905 bp[1] End 64,546,173 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 C3|12 33.73 cM Start 76,450,950 bp[2] End 76,453,712 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve middle frontal gyrus subthalamic nucleus external globus pallidus Medulla Oblongata pars reticulata internal globus pallidus superior vestibular nucleus Skeletal muscle tissue of rectus abdominis corpus callosum Top expressed in seminiferous tubule spermatocyte spermatid ascending aorta aortic valve dentate gyrus of hippocampal formation granule cell piriform cortex hippocampus proper supraoptic nucleus olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding unfolded protein binding protein binding enzyme binding ATP binding disordered domain specific binding glycolipid binding ATPase activity heat shock protein binding protein folding chaperone activity tau protein binding chaperone binding misfolded protein binding Cellular component cytoplasm cytosol blood microparticle membrane spindle extracellular exosome cytoskeleton nucleus synaptonemal complex male germ cell nucleus mitochondrion cell surface CatSper complex myelin sheath meiotic spindle plasma membrane Biological process cell differentiation negative regulation of inclusion body assembly response to heat response to unfolded protein protein refolding spermatogenesis response to cold positive regulation of protein phosphorylation male meiotic nuclear division male meiosis I spermatid development positive regulation of ATP-dependent activity synaptonemal complex disassembly positive regulation of ATPase-coupled calcium transmembrane transporter activity positive regulation of G2/M transition of mitotic cell cycle vesicle-mediated transport cellular response to heat Unfolded Protein Response chaperone cofactor-dependent protein refolding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3306 15512 Ensembl ENSG00000126803 ENSMUSG00000059970 UniProt P54652 P17156 RefSeq (mRNA) NM_021979 NM_001387931 NM_001002012 NM_008301 RefSeq (protein) NP_068814 NP_001002012 NP_032327 Location (UCSC) Chr 14: 64.54 – 64.55 Mb Chr 12: 76.45 – 76.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse