HSPB7

Heat Shock Protein Family B (small) member 7 (HSPB7) in humans is a protein encoded by a gene of the same name with four exons that is located on chromosome 1p36.13.^[4],.^[5] HSPB7 contains 170 amino acids and has a molecular weight of 18,611Da.^[6] HSPB7 is a member of human small heat shock protein (HSPB) family, which contains eleven family members of chaperone proteins.^[7] HSPB7 and its gene pair SRARP are located 5 kb apart on the opposite strands of chromosome 1p36.13.^[8]

HSPB7
Identifiers
Aliases	HSPB7, cvHSP, heat shock protein family B (small) member 7
External IDs	OMIM: 610692; MGI: 1352494; HomoloGene: 8480; GeneCards: HSPB7; OMA:HSPB7 - orthologs
Gene location (Mouse) Chr. Chromosome 4 (mouse)[1] Band 4|4 D3 Start 141,148,090 bp[1] End 141,152,622 bp[1]
Gene ontology Molecular function filamin binding protein C-terminus binding protein binding Cellular component cytoplasm aggresome Cajal body nucleus nucleoplasm actin cytoskeleton Biological process response to unfolded protein regulation of heart contraction heart development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27129 29818 Ensembl ENSG00000173641 ENSMUSG00000006221 UniProt Q9UBY9 P35385 RefSeq (mRNA) NM_014424 NM_013868 RefSeq (protein) NP_055239 NP_001336611 NP_001336612 NP_001336614 NP_001336615 NP_001336616 NP_001336617 NP_001336618 NP_038896 Location (UCSC) n/a Chr 4: 141.15 – 141.15 Mb PubMed search [2] [3]
Wikidata
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Expression and molecular function

HSPB7 is widely expressed throughout the body and its highest expression is observed in the cardiac tissue ^[7],.^[9] HSPB protein family, including HSPB7, act protectively on aggregation of several proteins containing an extended polyglutamine (polyQ) stretch that are linked to a variety of neurodegenerative diseases.^[10] Among these proteins, HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of chaperones.^[10] In addition, HSPB7 protein contains a HSP20 domain and strongly interacts with the chaperone protein 14-3-3.^[8] An interaction with the 14-3-3 protein is a common molecular feature between HSPB7 and SRARP proteins ^[8],[11]

Role in cardiomyopathy and Cancer

HSPB7 has cardiac protective functions and mutations in this gene leads to cardiomyopathies.^[10] It has been suggested that HSPB7 cardioprotective function is mediated by facilitating sarcomeric proteostasis.^[12] Furthermore, HSPB7 is widely inactivated in malignancies by copy-number loss and epigenetic silencing and the overexpression of this protein results in a tumor suppressor function in multiple cancer cell lines^[8],.^[13] The overexpression of HSPB7 and its gene pair SRARP lead to a reduction in the relative phosphorylation and/or expression of Akt and ERK in cancer cells.^[8] In addition, it has been suggested that HSBP7 is regulated by p53 tumor suppressor in renal cell carcinoma.^[13]

Approved Symbol	HSPB7
Approved Name	Heat shock protein family B (small) member 7
HGNC ID	HGNC:5249
Previous name	heat shock 27kD protein family, member 7 (cardiovascular)
Alias Symbols	cvHSP
Chromosome location	1p36.13
Ensembl	ENSG00000173641
UniProt	Q9UBY9
NCBI Gene	27129
RefSeq	NM_014424
UCSC	uc001axo.2
Protein Sequence	HSPB7 Protein Sequence (Ensembl)
Wikidata	Q18038659
PubMed	HSPB7 PubMed References