HSPH1

Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene.^[5][6][7]

HSPH1
Identifiers
Aliases	HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25, heat shock protein family H (Hsp110) member 1
External IDs	OMIM: 610703; MGI: 105053; HomoloGene: 21322; GeneCards: HSPH1; OMA:HSPH1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.3 Start 31,134,973 bp[1] End 31,162,388 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G3|5 89.18 cM Start 149,537,752 bp[2] End 149,559,841 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad bronchial epithelial cell nucleus accumbens postcentral gyrus caudate nucleus Brodmann area 23 putamen Region I of hippocampus proper Brodmann area 9 superior frontal gyrus Top expressed in tail of embryo genital tubercle primitive streak barrel cortex Paneth cell ventromedial nucleus facial motor nucleus arcuate nucleus utricle cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding alpha-tubulin binding protein binding ATP binding adenyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol endocytic vesicle lumen nucleoplasm extracellular region microtubule extracellular exosome nucleus protein-containing complex Biological process negative regulation of establishment of protein localization to mitochondrion positive regulation of protein tyrosine kinase activity negative regulation of p38MAPK cascade negative regulation of apoptotic signaling pathway receptor-mediated endocytosis chaperone cofactor-dependent protein refolding positive regulation of NK T cell activation response to unfolded protein regulation of cellular response to heat negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide positive regulation of MHC class I biosynthetic process positive regulation of transcription by RNA polymerase II regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10808 15505 Ensembl ENSG00000120694 ENSMUSG00000029657 UniProt Q92598 Q61699 RefSeq (mRNA) NM_001286503 NM_001286504 NM_001286505 NM_006644 NM_001349704 NM_013559 NM_001347534 RefSeq (protein) NP_001273432 NP_001273433 NP_001273434 NP_006635 NP_001336633 NP_001334463 NP_038587 Location (UCSC) Chr 13: 31.13 – 31.16 Mb Chr 5: 149.54 – 149.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

HSPH1 has been shown to interact with Cofilin 1.^[8]