Hemoglobin subunit zeta

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.^[5][6]

HBZ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JEB, 3W4U
Identifiers
Aliases	HBZ, HBZ-T1, HBZ1, hemoglobin subunit zeta, HBAZ
External IDs	OMIM: 142310; MGI: 96019; HomoloGene: 110705; GeneCards: HBZ; OMA:HBZ - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 142,728 bp[1] End 154,503 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A4|11 18.86 cM Start 32,226,400 bp[2] End 32,228,116 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis blood ganglionic eminence bone marrow subcutaneous adipose tissue anterior cingulate cortex amygdala ectocervix Top expressed in yolk sac tail of embryo genital tubercle abdominal wall maxillary prominence internal carotid artery mandibular prominence external carotid artery hand somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxygen binding protein binding heme binding metal ion binding oxygen carrier activity peroxidase activity haptoglobin binding organic acid binding Cellular component hemoglobin complex extracellular exosome haptoglobin-hemoglobin complex Biological process oxygen transport negative regulation of transcription by RNA polymerase II erythrocyte maturation transport hydrogen peroxide catabolic process protein heterooligomerization cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3050 15126 Ensembl ENSG00000130656 ENSMUSG00000055609 UniProt P02008 P06467 RefSeq (mRNA) NM_005332 NM_010405 RefSeq (protein) NP_005323 NP_034535 Location (UCSC) Chr 16: 0.14 – 0.15 Mb Chr 11: 32.23 – 32.23 Mb PubMed search [3] [4]
Wikidata
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Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.^[6]