Hepatoma-derived growth factor

Hepatoma-derived growth factor (HDGF) also known as high mobility group protein 1-like 2 (HMG-1L2) is a protein that in humans is encoded by the HDGF gene.^[5][6]

HDGF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RI0, 2NLU
Identifiers
Aliases	HDGF, HMG1L2, hepatoma-derived growth factor, heparin binding growth factor
External IDs	OMIM: 600339; MGI: 1194494; HomoloGene: 3306; GeneCards: HDGF; OMA:HDGF - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 156,742,109 bp[1] End 156,766,925 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 38.78 cM Start 87,813,628 bp[2] End 87,823,439 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence mucosa of ileum olfactory zone of nasal mucosa mucosa of transverse colon right uterine tube rectum skin of leg gastrocnemius muscle skin of abdomen Top expressed in otic placode otic vesicle saccule Ileal epithelium fetal liver hematopoietic progenitor cell epiblast lactiferous gland ventricular zone lip yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding DNA binding transcription corepressor binding transcription corepressor activity growth factor activity heparin binding RNA binding Cellular component cytoplasm transcription repressor complex nucleus nucleoplasm extracellular space extracellular matrix extracellular region collagen-containing extracellular matrix Biological process IRE1-mediated unfolded protein response cell population proliferation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated signal transduction cellular process or phenomenon regulation of signaling receptor activity cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3068 15191 Ensembl ENSG00000143321 ENSMUSG00000004897 UniProt P51858 P51859 RefSeq (mRNA) NM_001126050 NM_001126051 NM_004494 NM_001319186 NM_001319187 NM_001319188 NM_008231 NM_001331051 NM_001331052 RefSeq (protein) NP_001119522 NP_001119523 NP_001306115 NP_001306116 NP_001306117 NP_004485 NP_001317980 NP_001317981 NP_032257 Location (UCSC) Chr 1: 156.74 – 156.77 Mb Chr 3: 87.81 – 87.82 Mb PubMed search [3] [4]
Wikidata
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