HCN1

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.^[5][6][7][8]

HCN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U0Z
Identifiers
Aliases	HCN1, BCNG-1, BCNG1, EIEE24, HAC-2, hyperpolarization activated cyclic nucleotide gated potassium channel 1, GEFSP10, DEE24
External IDs	OMIM: 602780; MGI: 1096392; HomoloGene: 32093; GeneCards: HCN1; OMA:HCN1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p12 Start 45,254,948 bp[1] End 45,696,498 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D2.3|13 66.34 cM Start 117,738,856 bp[2] End 118,123,954 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 primary visual cortex trigeminal ganglion Brodmann area 46 spinal ganglia prefrontal cortex superior frontal gyrus middle temporal gyrus parietal lobe Top expressed in subiculum medial vestibular nucleus pontine nuclei deep cerebellar nuclei cerebellar vermis facial motor nucleus lobe of cerebellum lumbar spinal ganglion anterior horn of spinal cord inferior colliculi More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding intracellular cAMP-activated cation channel activity identical protein binding voltage-gated sodium channel activity ion channel activity potassium channel activity sodium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity voltage-gated cation channel activity cAMP binding protein binding Cellular component axon membrane dendrite plasma membrane integral component of membrane HCN channel complex integral component of plasma membrane Biological process transmembrane transport retinal cone cell development regulation of ion transmembrane transport apical protein localization ion transport sodium ion transport regulation of membrane potential sodium ion transmembrane transport potassium ion transmembrane transport potassium ion transport protein homotetramerization cellular response to cAMP Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 348980 15165 Ensembl ENSG00000164588 ENSMUSG00000021730 UniProt O60741 O88704 RefSeq (mRNA) NM_021072 NM_010408 RefSeq (protein) NP_066550 NP_034538 Location (UCSC) Chr 5: 45.25 – 45.7 Mb Chr 13: 117.74 – 118.12 Mb PubMed search [3] [4]
Wikidata
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Function

Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.^[8]

Tissue distribution

HCN1 channel expression is found in the sinoatrial node,^[9][10] the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.^{[11][12][13][14][15]}

Ligands

• Ketamine is an inhibitor of HCN1 in addition to its other targets.^[16][17]

• Propofol also inhibits HCN1.^[18]

• Isoflurane and Sevoflurane inhibit HCN1.^[19]

Interactions

HCN1 has been shown to interact with HCN2.^[20][21]

Epilepsy

De novo mutations in HCN1 cause epilepsy.^[22]

See also

• Cyclic nucleotide-gated ion channel