HCN2

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene.^[5][6][7][8]

HCN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MPF, 3U10
Identifiers
Aliases	HCN2, BCNG-2, BCNG2, HAC-1, hyperpolarization activated cyclic nucleotide gated potassium channel 2, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2, EIG17, FEB2, GEFSP11
External IDs	OMIM: 602781; MGI: 1298210; HomoloGene: 31022; GeneCards: HCN2; OMA:HCN2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 589,881 bp[1] End 617,159 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 79,552,468 bp[2] End 79,571,942 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment right frontal lobe putamen nucleus accumbens anterior cingulate cortex caudate nucleus Brodmann area 10 Brodmann area 9 amygdala right hemisphere of cerebellum Top expressed in perirhinal cortex entorhinal cortex primary visual cortex superior frontal gyrus CA3 field choroid plexus of fourth ventricle central gray substance of midbrain cerebellar cortex medulla oblongata lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding potassium channel activity cAMP binding sodium channel activity voltage-gated ion channel activity ion channel activity intracellular cAMP-activated cation channel activity identical protein binding voltage-gated potassium channel activity voltage-gated sodium channel activity protein binding Cellular component integral component of membrane membrane voltage-gated potassium channel complex plasma membrane integral component of plasma membrane HCN channel complex Biological process cellular response to cGMP sodium ion transmembrane transport sodium ion transport cell-cell signaling regulation of membrane potential regulation of ion transmembrane transport ion transport potassium ion transport transmembrane transport potassium ion transmembrane transport cellular response to cAMP membrane depolarization during cardiac muscle cell action potential sodium ion import across plasma membrane potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 610 15166 Ensembl ENSG00000099822 ENSMUSG00000020331 UniProt Q9UL51 O88703 RefSeq (mRNA) NM_001194 NM_008226 RefSeq (protein) NP_001185 NP_032252 Location (UCSC) Chr 19: 0.59 – 0.62 Mb Chr 10: 79.55 – 79.57 Mb PubMed search [3] [4]
Wikidata
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Interactions

HCN2 has been shown to interact with HCN1^[9][10] and HCN4.^[9]

Function

The function of the channel is not known although its activation by hyperpolarization alludes to the funny channels in the sinoatrial node of the heart (which form the basis of spontaneous generation of electrical rhythm). These channels have recently been associated with chronic pain and blocking the gene is associated with resolution of neuropathic episodes of pain.^[11]

See also

• Cyclic nucleotide-gated ion channel