ICMT

For the physics institute, see Institute for Condensed Matter Theory.

Protein-S-isoprenylcysteine O-methyltransferase is an enzyme that in humans is encoded by the ICMT gene.^[5][6][7]

ICMT
Identifiers
Aliases	ICMT, HSTE14, MST098, MSTP098, PCCMT, PCMT, PPMT, isoprenylcysteine carboxyl methyltransferase, ICMT protein, human
External IDs	OMIM: 605851; MGI: 1888594; HomoloGene: 5735; GeneCards: ICMT; OMA:ICMT - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.31 Start 6,221,193 bp[1] End 6,235,972 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 152,297,227 bp[2] End 152,307,121 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thoracic diaphragm stromal cell of endometrium body of tongue olfactory zone of nasal mucosa gastrocnemius muscle islet of Langerhans nasal epithelium right ventricle glutes muscle of thigh Top expressed in neural layer of retina lobe of cerebellum cerebellar vermis spermatocyte lumbar spinal ganglion spermatid retinal pigment epithelium lip dentate gyrus of hippocampal formation granule cell right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity protein C-terminal carboxyl O-methyltransferase activity protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process post-translational protein modification methylation protein targeting to membrane C-terminal protein methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23463 57295 Ensembl ENSG00000116237 ENSMUSG00000039662 UniProt O60725 Q9EQK7 RefSeq (mRNA) NM_012405 NM_170705 NM_133788 RefSeq (protein) NP_036537 NP_598549 Location (UCSC) Chr 1: 6.22 – 6.24 Mb Chr 4: 152.3 – 152.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.^[7]