IFI30

Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene.^[5][6][7]

IFI30
Identifiers
Aliases	IFI30, GILT, IFI-30, IP30, IP-30, lysosomal thiol reductase, IFI30 lysosomal thiol reductase
External IDs	OMIM: 604664; MGI: 2137648; HomoloGene: 38171; GeneCards: IFI30; OMA:IFI30 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,173,162 bp[1] End 18,178,117 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 71,215,419 bp[2] End 71,219,307 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood appendix spleen upper lobe of left lung right lung lymph node duodenum right adrenal cortex Top expressed in spleen duodenum colon yolk sac jejunum stomach ileum thymus zone of skin lip More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity protein binding oxidoreductase activity, acting on a sulfur group of donors Cellular component extracellular region cell junction lysosomal lumen intracellular membrane-bounded organelle lysosome cytosol Biological process interferon-gamma-mediated signaling pathway immune system process antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen via MHC class I Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10437 65972 Ensembl ENSG00000216490 ENSMUSG00000031838 UniProt P13284 Q9ESY9 RefSeq (mRNA) NM_006332 NM_023065 RefSeq (protein) NP_006323 NP_075552 Location (UCSC) Chr 19: 18.17 – 18.18 Mb Chr 8: 71.22 – 71.22 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.^[7]