IFIT2

Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the IFIT2 gene.^[5][6][7] Previously, this gene was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 protein.^[8] The IFIT2 gene is one of the many genes that are stimulated by type 1 interferons to form their messenger RNAs and thereby their product proteins. Consequently, the IFIT2 gene is classified as one of the many type 1 interferon-stimulated genes.^[8][9][10]

IFIT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4G1T
Identifiers
Aliases	IFIT2, G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42, interferon induced protein with tetratricopeptide repeats 2, ISG-54
External IDs	OMIM: 147040; MGI: 99449; HomoloGene: 1187; GeneCards: IFIT2; OMA:IFIT2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.31 Start 89,283,694 bp[1] End 89,309,271 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 34,528,094 bp[2] End 34,553,819 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva inferior ganglion of vagus nerve trigeminal ganglion subthalamic nucleus visceral pleura white blood cell monocyte external globus pallidus parietal pleura spinal ganglia Top expressed in iris mammillary body lumbar spinal ganglion decidua endothelial cell of lymphatic vessel blood ciliary body sciatic nerve medial geniculate nucleus medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm cytosol endoplasmic reticulum Biological process apoptotic process positive regulation of apoptotic process response to virus innate immune response defense response to virus negative regulation of protein binding apoptotic mitochondrial changes type I interferon signaling pathway cellular response to interferon-alpha immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3433 15958 Ensembl ENSG00000119922 ENSMUSG00000045932 UniProt P09913 Q64112 RefSeq (mRNA) NM_001547 NM_008332 NM_001355262 RefSeq (protein) NP_001538 NP_032358 NP_001342191 Location (UCSC) Chr 10: 89.28 – 89.31 Mb Chr 19: 34.53 – 34.55 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

IFIT2 may play a role in preventing tumor progression.^[11] Indeed, IFIT2 gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[12] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[12]