IFIT3

Interferon-induced protein with tetratricopeptide repeats 3, also known as interferon-stimulated gene 49 (ISG49),^[5] is a protein that in humans is encoded by the IFIT3 gene.^[5][6][7][8] It plays a part in the innate immune response to viruses in response to type I interferon signaling.^[5]

IFIT3
Identifiers
Aliases	IFIT3, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41, interferon induced protein with tetratricopeptide repeats 3
External IDs	OMIM: 604650; MGI: 1101055; HomoloGene: 1189; GeneCards: IFIT3; OMA:IFIT3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.31 Start 89,327,307 bp[1] End 89,377,473 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 34,560,931 bp[2] End 34,566,131 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion jejunal mucosa pericardium lower lobe of lung spinal ganglia human penis palpebral conjunctiva monocyte endothelial cell synovial joint Top expressed in right kidney granulocyte human kidney thymus jejunum lung colon adrenal gland spleen embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function identical protein binding protein binding molecular function RNA binding Cellular component cytoplasm mitochondrion cytosol Biological process immune system process response to virus innate immune response negative regulation of apoptotic process defense response to virus type I interferon signaling pathway negative regulation of cell population proliferation cellular response to interferon-alpha response to bacterium cellular response to interferon-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3437 15959 Ensembl ENSG00000119917 ENSMUSG00000074896 UniProt O14879 Q64345 RefSeq (mRNA) NM_001549 NM_001031683 NM_001289758 NM_001289759 NM_010501 RefSeq (protein) NP_001026853 NP_001276687 NP_001276688 NP_001540 NP_034631 Location (UCSC) Chr 10: 89.33 – 89.38 Mb Chr 19: 34.56 – 34.57 Mb PubMed search [3] [4]
Wikidata
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