IFNAR1

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.^[5][6]

IFNAR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3S98, 3SE3, 3SE4, 4PO6
Identifiers
Aliases	IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, interferon alpha and beta receptor subunit 1
External IDs	OMIM: 107450; MGI: 107658; HomoloGene: 524; GeneCards: IFNAR1; OMA:IFNAR1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 33,324,429 bp[1] End 33,359,864 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C3.3|16 52.98 cM Start 91,282,126 bp[2] End 91,304,329 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte rectum gallbladder ventricular zone islet of Langerhans endothelial cell Achilles tendon blood epithelium of colon stromal cell of endometrium Top expressed in genital tubercle tail of embryo granulocyte Rostral migratory stream vas deferens aortic valve stroma of bone marrow cumulus cell thymus ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interferon receptor activity protein binding interleukin-10 receptor activity type I interferon receptor activity type I interferon binding cytokine receptor activity Cellular component integral component of membrane endosome late endosome membrane plasma membrane lysosome integral component of plasma membrane Biological process receptor signaling pathway via JAK-STAT response to virus cytokine-mediated signaling pathway response to lipopolysaccharide cellular response to interferon-alpha type I interferon signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3454 15975 Ensembl ENSG00000142166 ENSMUSG00000022967 UniProt P17181 P33896 RefSeq (mRNA) NM_000629 NM_010508 RefSeq (protein) NP_000620 NP_034638 Location (UCSC) Chr 21: 33.32 – 33.36 Mb Chr 16: 91.28 – 91.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for type I interferons, including interferon-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.^[6]

Interactions

IFNAR1 has been shown to interact with:

• PRMT1,^[7]
• STAT2,^[8][9][10] and
• Tyrosine kinase 2.^[11][12]