IFNB1

Interferon beta is a protein that in humans is encoded by the IFNB1 gene.^[5] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.

IFNB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AU1
Identifiers
Aliases	IFNB1, IFB, IFF, IFNB, IFN-beta, interferon beta 1
External IDs	OMIM: 147640; MGI: 107657; HomoloGene: 1640; GeneCards: IFNB1; OMA:IFNB1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.3 Start 21,077,104 bp[1] End 21,077,942 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C4|4 41.91 cM Start 88,440,262 bp[2] End 88,441,011 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad bone granulocyte epithelium of colon bone marrow islet of Langerhans upper lobe of lung upper lobe of left lung left lobe of thyroid gland Top expressed in sternocleidomastoid muscle triceps brachii muscle temporal muscle digastric muscle artery skin of abdomen carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity cytokine receptor binding chloramphenicol O-acetyltransferase activity type I interferon receptor binding Cellular component extracellular space extracellular region Biological process positive regulation of peptidyl-serine phosphorylation of STAT protein blood coagulation B cell differentiation cellular response to interferon-beta regulation of MHC class I biosynthetic process negative regulation of viral genome replication natural killer cell activation B cell activation involved in immune response positive regulation of apoptotic signaling pathway cell surface receptor signaling pathway natural killer cell activation involved in immune response response to exogenous dsRNA response to virus T cell activation involved in immune response positive regulation of transcription by RNA polymerase II defense response negative regulation of T cell differentiation positive regulation of innate immune response cellular response to exogenous dsRNA negative regulation of T-helper 2 cell cytokine production defense response to virus type I interferon signaling pathway regulation of signaling receptor activity humoral immune response B cell proliferation adaptive immune response cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3456 15977 Ensembl ENSG00000171855 ENSMUSG00000048806 UniProt P01574 P01575 RefSeq (mRNA) NM_002176 NM_010510 RefSeq (protein) NP_002167 NP_034640 Location (UCSC) Chr 9: 21.08 – 21.08 Mb Chr 4: 88.44 – 88.44 Mb PubMed search [3] [4]
Wikidata
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Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.