IFT81

Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene.^[5][6] Together with IFT74/72 it forms a core complex to build IFT particles^[7] which are required for cilium formation. Additionally, it interacts with basal body components as CEP170^[8] which regulates the disassembly of the cilium.

IFT81
Identifiers
Aliases	IFT81, CDV-1, CDV-1R, CDV1, CDV1R, DV1, intraflagellar transport 81, SRTD19
External IDs	OMIM: 605489; MGI: 1098597; HomoloGene: 7664; GeneCards: IFT81; OMA:IFT81 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.11 Start 110,124,335 bp[1] End 110,218,793 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 62.44 cM Start 122,688,267 bp[2] End 122,752,581 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell ventricular zone right uterine tube ganglionic eminence Achilles tendon olfactory zone of nasal mucosa testicle Epithelium of choroid plexus left testis right testis Top expressed in spermatid saccule spermatocyte neural layer of retina interventricular septum genital tubercle otic vesicle vestibular sensory epithelium right ventricle olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function tubulin binding protein binding Cellular component intraciliary transport particle B ciliary basal body centrosome sperm principal piece cell projection ciliary tip motile cilium sperm midpiece cilium Biological process cell projection organization spermatogenesis intraciliary transport intraciliary transport involved in cilium assembly cilium assembly regulation of smoothened signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28981 12589 Ensembl ENSG00000122970 ENSMUSG00000029469 UniProt Q8WYA0 O35594 RefSeq (mRNA) NM_001143779 NM_014055 NM_031473 NM_001347946 NM_001347947 NM_001347948 NM_009879 NM_001358917 NM_001358918 NM_001358919 RefSeq (protein) NP_001137251 NP_054774 NP_113661 NP_001334875 NP_001334876 NP_001334877 NP_001137251.1 NP_054774.2 NP_034009 NP_001345846 NP_001345847 NP_001345848 Location (UCSC) Chr 12: 110.12 – 110.22 Mb Chr 5: 122.69 – 122.75 Mb PubMed search [3] [4]
Wikidata
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