IGFBP2

Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene.^[5]

IGFBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H7T
Identifiers
Aliases	IGFBP2, IBP2, IGF-BP53, insulin like growth factor binding protein 2
External IDs	OMIM: 146731; MGI: 96437; HomoloGene: 499; GeneCards: IGFBP2; OMA:IGFBP2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 216,632,828 bp[1] End 216,664,436 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 36.94 cM Start 72,863,662 bp[2] End 72,891,633 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta decidua right coronary artery body of stomach ventricular zone ganglionic eminence olfactory zone of nasal mucosa epithelium of bronchus bronchial epithelial cell Top expressed in choroid plexus of fourth ventricle calvaria vestibular sensory epithelium Epithelium of choroid plexus corneal stroma efferent ductule optic nerve transitional epithelium of urinary bladder left lobe of liver molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin-like growth factor binding growth factor binding insulin-like growth factor I binding insulin-like growth factor II binding protein binding signaling receptor binding Cellular component extracellular region apical plasma membrane extracellular exosome cytoplasmic vesicle extracellular space Biological process response to estradiol response to retinoic acid response to nutrient female pregnancy response to steroid hormone response to mechanical stimulus ageing response to glucocorticoid response to lithium ion response to estrogen regulation of insulin-like growth factor receptor signaling pathway cellular response to hormone stimulus regulation of cell growth regulation of growth negative regulation of canonical Wnt signaling pathway signal transduction positive regulation of activated T cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3485 16008 Ensembl ENSG00000115457 ENSMUSG00000039323 UniProt P18065 P47877 RefSeq (mRNA) NM_001313990 NM_001313992 NM_001313993 NM_000597 NM_008342 NM_001310659 RefSeq (protein) NP_000588 NP_001300919 NP_001300921 NP_001300922 NP_001297588 NP_032368 Location (UCSC) Chr 2: 216.63 – 216.66 Mb Chr 1: 72.86 – 72.89 Mb PubMed search [3] [4]
Wikidata
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