IGFBP5

Insulin-like growth factor-binding protein 5 (IBF-5) is a protein that in humans is encoded by the IGFBP5 gene.^[5] An IGFBP5 gene was recently identified as being important for adaptation to varying water salinity in fish.^[6]

IGFBP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BOE, 1H59
Identifiers
Aliases	IGFBP5, IBP5, insulin like growth factor binding protein 5
External IDs	OMIM: 146734; MGI: 96440; HomoloGene: 56489; GeneCards: IGFBP5; OMA:IGFBP5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 216,672,105 bp[1] End 216,695,549 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C3|1 36.94 cM Start 72,897,091 bp[2] End 72,914,043 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla urethra saphenous vein nipple vena cava cardia pylorus canal of the cervix left uterine tube right ovary Top expressed in ciliary body external carotid artery molar lactiferous gland saccule extraocular muscle ankle otic placode otic vesicle internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibronectin binding insulin-like growth factor binding growth factor binding insulin-like growth factor I binding insulin-like growth factor II binding protein binding Cellular component insulin-like growth factor ternary complex extracellular region insulin-like growth factor binding protein complex endoplasmic reticulum lumen extracellular space Biological process negative regulation of smooth muscle cell proliferation negative regulation of translation positive regulation of protein kinase B signaling intracellular signal transduction negative regulation of growth glucose homeostasis female pregnancy cellular response to organic cyclic compound negative regulation of smooth muscle cell migration negative regulation of osteoblast differentiation regulation of glucose metabolic process negative regulation of cell migration positive regulation of insulin-like growth factor receptor signaling pathway regulation of cell growth osteoblast differentiation response to growth hormone glucose metabolic process negative regulation of insulin-like growth factor receptor signaling pathway hair follicle morphogenesis regulation of growth negative regulation of muscle tissue development striated muscle cell differentiation lung alveolus development negative regulation of skeletal muscle hypertrophy type B pancreatic cell proliferation cellular response to cAMP signal transduction mammary gland involution ageing post-translational protein modification positive regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration regulation of insulin-like growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3488 16011 Ensembl ENSG00000115461 ENSMUSG00000026185 UniProt P24593 Q07079 RefSeq (mRNA) NM_000599 NM_010518 RefSeq (protein) NP_000590 NP_034648 Location (UCSC) Chr 2: 216.67 – 216.7 Mb Chr 1: 72.9 – 72.91 Mb PubMed search [3] [4]
Wikidata
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