IGSF8

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.^[5][6][7] IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.^[8] IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor).^[8] IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer,^[8] and has been proposed as a potential therapeutic target in gliomas.^[9] In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.^[8]

IGSF8
Identifiers
Aliases	IGSF8, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8
External IDs	OMIM: 606644; MGI: 2154090; HomoloGene: 14163; GeneCards: IGSF8; OMA:IGSF8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2 Start 160,091,340 bp[1] End 160,098,943 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.59 cM Start 172,089,208 bp[2] End 172,147,408 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe Brodmann area 9 C1 segment prefrontal cortex cingulate gyrus anterior cingulate cortex putamen hypothalamus nucleus accumbens Top expressed in ventricular zone primary visual cortex superior frontal gyrus dorsomedial hypothalamic nucleus dentate gyrus of hippocampal formation granule cell subiculum perirhinal cortex superior colliculus respiratory epithelium nasal epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component extracellular exosome membrane integral component of membrane plasma membrane Biological process skeletal muscle tissue development nervous system development cell population proliferation single fertilization cell motility Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 93185 140559 Ensembl ENSG00000162729 ENSMUSG00000038034 UniProt Q969P0 Q8R366 RefSeq (mRNA) NM_001206665 NM_052868 NM_001320247 NM_080419 RefSeq (protein) NP_001193594 NP_001307176 NP_443100 NP_536344 Location (UCSC) Chr 1: 160.09 – 160.1 Mb Chr 1: 172.09 – 172.15 Mb PubMed search [3] [4]
Wikidata
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Cancer biomarker

In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker.^[9] IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.^[10]