IHPK2

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene.^[4][5]

IP6K2
Identifiers
Aliases	IP6K2, IHPK2, PIUS, inositol hexakisphosphate kinase 2, InsP6K2
External IDs	OMIM: 606992; MGI: 1923750; HomoloGene: 56929; GeneCards: IP6K2; OMA:IP6K2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 48,688,003 bp[1] End 48,740,353 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum ganglionic eminence tibial nerve skin of abdomen skin of leg right uterine tube mucosa of transverse colon body of uterus anterior pituitary left ovary n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity inositol hexakisphosphate 5-kinase activity transferase activity inositol hexakisphosphate 1-kinase activity nucleotide binding protein binding ATP binding inositol hexakisphosphate 3-kinase activity inositol-1,3,4,5,6-pentakisphosphate kinase activity inositol 5-diphosphate pentakisphosphate 5-kinase activity inositol diphosphate tetrakisphosphate kinase activity inositol heptakisphosphate kinase activity inositol hexakisphosphate kinase activity flavonoid binding Cellular component nucleus nucleoplasm fibrillar center cell junction intermediate filament cytoskeleton Biological process phosphate ion transport phosphatidylinositol phosphate biosynthetic process inositol phosphate metabolic process type I interferon signaling pathway negative regulation of cell growth phosphorylation positive regulation of apoptotic process inositol phosphate biosynthetic process cellular response to flavonoid lipid metabolism phosphatidylinositol metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51447 76500 Ensembl ENSG00000068745 ENSMUSG00000032599 UniProt Q9UHH9 Q80V72 RefSeq (mRNA) NM_001005909 NM_001005910 NM_001005911 NM_001005912 NM_001005913 NM_001146178 NM_001146179 NM_001190316 NM_001190317 NM_016291 NM_029634 RefSeq (protein) NP_001005909 NP_001005910 NP_001005911 NP_001139650 NP_001139651 NP_001177245 NP_001177246 NP_057375 NP_083910 NP_001366529 NP_001366530 NP_001366531 NP_001366532 Location (UCSC) Chr 3: 48.69 – 48.74 Mb n/a PubMed search [2] [3]
Wikidata
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This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.^[5]