IKZF3

Zinc finger protein Aiolos, also known as Ikaros family zinc finger protein 3, is a protein encoded in humans by the IKZF3 gene.^[5][6][7]

IKZF3
Identifiers
Aliases	IKZF3, AIO, AIOLOS, ZNFN1A3, IKAROS family zinc finger 3, IMD84
External IDs	OMIM: 606221; MGI: 1342542; HomoloGene: 8269; GeneCards: IKZF3; OMA:IKZF3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12-q21.1 Start 39,757,718 bp[1] End 39,864,312 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 98,355,728 bp[2] End 98,436,857 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte lymph node epithelium of nasopharynx bone marrow cell thymus spleen blood tonsil superficial temporal artery appendix Top expressed in mesenteric lymph nodes thymus spleen blood lumbar subsegment of spinal cord female urethra subcutaneous adipose tissue submandibular gland granulocyte transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein homodimerization activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding protein binding protein heterodimerization activity nucleic acid binding identical protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm plasma membrane nucleus nucleoplasm cytosol Biological process regulation of apoptotic process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated B cell activation regulation of B cell proliferation regulation of lymphocyte differentiation mesoderm development regulation of B cell differentiation positive regulation of transcription by RNA polymerase II response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22806 22780 Ensembl ENSG00000161405 ENSMUSG00000018168 UniProt Q9UKT9 O08900 RefSeq (mRNA) NM_183232 NM_001257408 NM_001257409 NM_001257410 NM_001257411 NM_001257412 NM_001257413 NM_001257414 NM_001284514 NM_001284515 NM_001284516 NM_012481 NM_183228 NM_183229 NM_183230 NM_183231 NM_011771 RefSeq (protein) NP_001244337 NP_001244338 NP_001244339 NP_001244340 NP_001244341 NP_001244342 NP_001244343 NP_001271443 NP_001271444 NP_001271445 NP_036613 NP_899051 NP_899052 NP_899053 NP_899054 NP_899055 NP_035901 Location (UCSC) Chr 17: 39.76 – 39.86 Mb Chr 11: 98.36 – 98.44 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. The regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.^[7]

Interactions

IKZF3 has been shown to interact with BCL2-like 1^[8] and HRAS.^[9]