IKZF4

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.^[5][6]

IKZF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MA7
Identifiers
Aliases	IKZF4, EOS, ZNFN1A4, IKAROS family zinc finger 4
External IDs	OMIM: 606239; MGI: 1343139; HomoloGene: 69103; GeneCards: IKZF4; OMA:IKZF4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 56,007,659 bp[1] End 56,038,435 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,466,712 bp[2] End 128,505,227 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell left adrenal gland adrenal cortex left adrenal cortex right adrenal gland inferior ganglion of vagus nerve muscle of thigh right adrenal cortex testicle gastrocnemius muscle Top expressed in Rostral migratory stream secondary oocyte zygote primary oocyte medulla of thymus female urethra trigeminal ganglion suprachiasmatic nucleus supraoptic nucleus yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity nucleic acid binding sequence-specific DNA binding DNA binding bHLH transcription factor binding protein homodimerization activity metal ion binding protein heterodimerization activity zinc ion binding protein domain specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm nuclear body protein-containing complex Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein homooligomerization protein heterooligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64375 22781 Ensembl ENSG00000123411 ENSMUSG00000002578 UniProt Q9H2S9 Q8C208 RefSeq (mRNA) NM_022465 NM_001351089 NM_001351090 NM_001351091 NM_001351092 NM_011772 NM_001358536 NM_001358537 RefSeq (protein) NP_071910 NP_001338018 NP_001338019 NP_001338020 NP_001338021 NP_035902 NP_001345465 NP_001345466 Location (UCSC) Chr 12: 56.01 – 56.04 Mb Chr 10: 128.47 – 128.51 Mb PubMed search [3] [4]
Wikidata
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Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]^[6]

Interactions

IKZF4 has been shown to interact with CTBP1^[7] and IKZF1.^[5][8]