IL17RB

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.^[5][6][7]

IL17RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VBC
Identifiers
Aliases	IL17RB, CRL4, EVI27, IL17BR, IL17RH1, interleukin 17 receptor B
External IDs	OMIM: 605458; MGI: 1355292; HomoloGene: 10287; GeneCards: IL17RB; OMA:IL17RB - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.1 Start 53,846,568 bp[1] End 53,865,794 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A3|14 18.39 cM Start 29,718,092 bp[2] End 29,730,853 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule right lobe of liver human kidney mucosa of ileum right hemisphere of cerebellum glomerulus amygdala metanephric glomerulus caudate nucleus nucleus accumbens Top expressed in secondary oocyte primary oocyte thymus zygote right kidney proximal tubule pharynx morula vestibular membrane of cochlear duct Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity interleukin-17 receptor activity Cellular component cytoplasm integral component of membrane extracellular region cell surface integral component of plasma membrane membrane plasma membrane Biological process defense response positive regulation of inflammatory response regulation of cell growth interleukin-17-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55540 50905 Ensembl ENSG00000056736 ENSMUSG00000015966 UniProt Q9NRM6 Q9JIP3 RefSeq (mRNA) NM_018725 NM_172234 NM_019583 RefSeq (protein) NP_061195 NP_062529 Location (UCSC) Chr 3: 53.85 – 53.87 Mb Chr 14: 29.72 – 29.73 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.^[7]

See also

• Interleukin-17 receptor