IL18RAP

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene.^[5][6]

IL18RAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WO4
Identifiers
Aliases	IL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL, IL18RB, interleukin 18 receptor accessory protein
External IDs	OMIM: 604509; MGI: 1338888; HomoloGene: 2859; GeneCards: IL18RAP; OMA:IL18RAP - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.1 Start 102,418,689 bp[1] End 102,452,565 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 40,554,522 bp[2] End 40,590,865 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood bone marrow spleen trabecular bone right lung bone marrow cell upper lobe of left lung periodontal fiber appendix Top expressed in granulocyte blood tibiofemoral joint embryo bone marrow spleen zygote endothelial cell of lymphatic vessel carotid body subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity interleukin-18 receptor activity Cellular component integral component of membrane membrane plasma membrane interleukin-18 receptor complex Biological process cell surface receptor signaling pathway inflammatory response immune response cellular response to cytokine stimulus signal transduction cellular response to hydrogen peroxide cell population proliferation interleukin-6 production T-helper 1 cell cytokine production neutrophil activation positive regulation of natural killer cell mediated cytotoxicity cellular response to interleukin-18 interleukin-18-mediated signaling pathway positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8807 16174 Ensembl ENSG00000115607 ENSMUSG00000026068 UniProt O95256 Q9Z2B1 RefSeq (mRNA) NM_003853 NM_010553 RefSeq (protein) NP_003844 NP_034683 Location (UCSC) Chr 2: 102.42 – 102.45 Mb Chr 1: 40.55 – 40.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18.^[5]

Disease association

Variants at IL18RAP have been linked to susceptibility to Coeliac disease.^[7]

See also

• Interleukin-18 receptor