IL1F10

"IL-38" redirects here. For the aircraft, see Ilyushin Il-38. For the road, see Illinois Route 38.

Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene.^[5][6][7][8]

IL1F10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5BOW
Identifiers
Aliases	IL1F10, FIL1-theta, IL-1HY2, IL-38, IL1-theta, IL1HY2, FKSG75, interleukin 1 family member 10 (theta), interleukin 1 family member 10
External IDs	OMIM: 615296; MGI: 2652548; HomoloGene: 17690; GeneCards: IL1F10; OMA:IL1F10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.1 Start 113,067,970 bp[1] End 113,075,843 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 16.32 cM Start 24,181,208 bp[2] End 24,183,832 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of limb skin of leg skin of abdomen skin of thigh human penis amniotic fluid gonad pharynx tonsil placenta Top expressed in lip skin of abdomen skin of external ear skin of back hair follicle cervix thymus More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity interleukin-1 receptor binding Cellular component extracellular space extracellular region Biological process inflammatory response immune response regulation of signaling receptor activity cytokine-mediated signaling pathway cellular response to cytokine stimulus neutrophil chemotaxis positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84639 215274 Ensembl ENSG00000136697 ENSMUSG00000046845 UniProt Q8WWZ1 Q8R459 RefSeq (mRNA) NM_173161 NM_032556 NM_153077 RefSeq (protein) NP_115945 NP_775184 NP_694717 Location (UCSC) Chr 2: 113.07 – 113.08 Mb Chr 2: 24.18 – 24.18 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.^[8]