IMPDH2

Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene.^[5][6][7]

IMPDH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B3O, 1NF7, 1NFB
Identifiers
Aliases	IMPDH2, IMPD2, IMPDH-II, IMP (inosine 5'-monophosphate) dehydrogenase 2, inosine monophosphate dehydrogenase 2
External IDs	OMIM: 146691; MGI: 109367; HomoloGene: 48919; GeneCards: IMPDH2; OMA:IMPDH2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,024,325 bp[1] End 49,029,447 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 108,437,485 bp[2] End 108,442,783 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary body of pancreas cartilage tissue right ovary right uterine tube gingival epithelium ventricular zone canal of the cervix skin of leg vulva Top expressed in morula epiblast uterus ventricular zone embryo embryo blastocyst spermatid yolk sac ovary More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding catalytic activity protein binding RNA binding oxidoreductase activity nucleotide binding IMP dehydrogenase activity Cellular component cytoplasm membrane peroxisomal membrane extracellular exosome nucleus extracellular region cytosol secretory granule lumen ficolin-1-rich granule lumen Biological process cellular response to interleukin-4 purine nucleotide biosynthetic process retina development in camera-type eye purine ribonucleoside monophosphate biosynthetic process lymphocyte proliferation GMP biosynthetic process protein homotetramerization GTP biosynthetic process neutrophil degranulation circadian rhythm Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3615 23918 Ensembl ENSG00000178035 ENSMUSG00000062867 UniProt P12268 P24547 RefSeq (mRNA) NM_000884 NM_011830 NM_001378921 RefSeq (protein) NP_000875 NP_035960 NP_001365850 Location (UCSC) Chr 3: 49.02 – 49.03 Mb Chr 9: 108.44 – 108.44 Mb PubMed search [3] [4]
Wikidata
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Function

IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate.^[5] IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A.^[8]

Clinical significance

This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.^[5]

See also

• IMP dehydrogenase