InaD-like protein

InaD-like protein is a protein that in humans is encoded by the PATJ gene.^[5][6][7]

PATJ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VF6, 2D92, 2DAZ, 2DB5, 2DLU, 2DM8, 2DMZ, 2EHR, 4Q2N
Identifiers
Aliases	PATJ, Cipp, InaD-like, hINADL, INADL, crumbs cell polarity complex component, PATJ crumbs cell polarity complex component
External IDs	OMIM: 603199; MGI: 1277960; HomoloGene: 72199; GeneCards: PATJ; OMA:PATJ - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 61,742,477 bp[1] End 62,178,675 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C6 Start 98,284,022 bp[2] End 98,607,840 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle renal medulla pons cerebellar cortex cerebellar hemisphere Achilles tendon right hemisphere of cerebellum Skeletal muscle tissue of rectus abdominis gingival epithelium cerebellar vermis Top expressed in cerebellar vermis lateral geniculate nucleus lobe of cerebellum medial dorsal nucleus medial geniculate nucleus motor neuron facial motor nucleus anterior horn of spinal cord inferior colliculi deep cerebellar nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm perinuclear region of cytoplasm plasma membrane apical part of cell extracellular exosome apical plasma membrane membrane bicellular tight junction centrosome microtubule organizing center cytosol cell junction protein-containing complex Biological process intracellular signal transduction bicellular tight junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10207 12695 Ensembl ENSG00000132849 ENSMUSG00000061859 UniProt Q8NI35 Q63ZW7 RefSeq (mRNA) NM_005799 NM_176877 NM_176878 NM_001350145 NM_001005784 NM_001005787 NM_007704 NM_172696 NM_001355177 RefSeq (protein) NP_795352 NP_001337074 NP_001005784 NP_001005787 NP_031730 NP_766284 NP_001342106 Location (UCSC) Chr 1: 61.74 – 62.18 Mb Chr 4: 98.28 – 98.61 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.^[7]

Interactions

INADL has been shown to interact with MPP5.^[8]