MPP5

MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene.^[5][6] Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM]^[6]

PALS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y76, 3UIT, 4UU5, 4UU6, 4WSI
Identifiers
Aliases	PALS1, membrane palmitoylated protein 5, protein associated with LIN7 1, MAGUK p55 family member, MPP5, protein associated with LIN7 1, MAGUK family member
External IDs	OMIM: 606958; MGI: 1927339; HomoloGene: 9512; GeneCards: PALS1; OMA:PALS1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.3 Start 67,240,713 bp[1] End 67,336,061 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 78,795,681 bp[2] End 78,887,488 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa ventricular zone germinal epithelium retinal pigment epithelium corpus callosum inferior ganglion of vagus nerve biceps brachii Skeletal muscle tissue of biceps brachii amniotic fluid corpus epididymis Top expressed in zygote tail of embryo spermatid otic placode genital tubercle saccule secondary oocyte otic vesicle left lung lobe epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding protein binding Cellular component cytoplasm membrane bicellular tight junction myelin sheath adaxonal region Schmidt-Lanterman incisure cell junction lateral loop extracellular exosome endomembrane system plasma membrane protein-containing complex Biological process establishment of epithelial cell polarity peripheral nervous system myelin maintenance protein localization to myelin sheath abaxonal region myelin assembly bicellular tight junction assembly plasma membrane organization morphogenesis of an epithelial sheet protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64398 56217 Ensembl ENSG00000072415 ENSMUSG00000021112 UniProt Q8N3R9 Q9JLB2 RefSeq (mRNA) NM_001256550 NM_022474 NM_019579 RefSeq (protein) NP_001243479 NP_071919 NP_062525 Location (UCSC) Chr 14: 67.24 – 67.34 Mb Chr 12: 78.8 – 78.89 Mb PubMed search [3] [4]
Wikidata
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Interactions

MPP5 has been shown to interact with INADL and FAM71D.^[5]