INF2

Inverted formin-2 is a protein that in humans is encoded by the INF2 gene.^[5][6] It belongs to the protein family called the formins. It has two splice isoforms, CAAX which localizes to the endoplasmic reticulum and non-CAAX which localizes to focal adhesions and the cytoplasm with enrichment at the Golgi.^[7][8] INF2 plays a role in mitochondrial fission and dorsal stress fiber formation.^[9] INF2 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments, but also accelerates disassembly of actin through encircling and severing filaments.^[10]

INF2
Identifiers
Aliases	INF2, C14orf151, C14orf173, CMTDIE, FSGS5, pp9484, inverted formin, FH2 and WH2 domain containing, inverted formin 2
External IDs	OMIM: 610982; MGI: 1917685; HomoloGene: 82406; GeneCards: INF2; OMA:INF2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.33 Start 104,681,146 bp[1] End 104,722,535 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F1 Start 112,588,784 bp[2] End 112,615,557 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve C1 segment mucosa of transverse colon right coronary artery gastric mucosa left coronary artery popliteal artery tibial arteries putamen right frontal lobe Top expressed in gastrula superior frontal gyrus olfactory tubercle decidua nucleus accumbens stroma of bone marrow primary visual cortex epithelium of lens transitional epithelium of urinary bladder renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding Cellular component cytoplasm perinuclear region of cytoplasm Biological process regulation of mitochondrial fission actin cytoskeleton organization cellular component organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64423 70435 Ensembl ENSG00000203485 ENSMUSG00000037679 UniProt Q27J81 Q0GNC1 RefSeq (mRNA) NM_001031714 NM_022489 NM_032714 NM_198411 RefSeq (protein) NP_001026884 NP_071934 NP_116103 NP_940803 NP_001361128 Location (UCSC) Chr 14: 104.68 – 104.72 Mb Chr 12: 112.59 – 112.62 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

It can be associated with Focal segmental glomerulosclerosis^[11] and Charcot-Marie-Tooth Disease.^[12]