ING2

Inhibitor of growth protein 2 is a protein that in humans is encoded by the ING2 gene.^[5][6]

ING2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WES, 2G6Q
Identifiers
Aliases	ING2, ING1L, p33inhibitor of growth family member 2
External IDs	OMIM: 604215; MGI: 1916510; HomoloGene: 20388; GeneCards: ING2; OMA:ING2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q35.1 Start 183,505,058 bp[1] End 183,512,429 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B1.1 Start 48,120,213 bp[2] End 48,128,591 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid jejunal mucosa right adrenal gland right adrenal cortex buccal mucosa cell left adrenal gland left adrenal cortex gonad palpebral conjunctiva bronchial epithelial cell Top expressed in lens epithelium of lens islet of Langerhans granulocyte epiblast seminiferous tubule renal corpuscle neural layer of retina yolk sac bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding chromatin binding metal ion binding methylated histone binding protein binding phosphatidylinositol binding protein-containing complex binding Cellular component Golgi apparatus plasma membrane Sin3 complex CCAAT-binding factor complex nucleus nucleoplasm cytosol Biological process flagellated sperm motility positive regulation of transforming growth factor beta receptor signaling pathway regulation of transcription, DNA-templated negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic signaling pathway male meiosis I transcription, DNA-templated positive regulation of transcription, DNA-templated male germ-line stem cell asymmetric division seminiferous tubule development spermatogenesis spermatid development regulation of growth regulation of response to DNA damage stimulus signal transduction negative regulation of cell population proliferation chromatin organization positive regulation of histone deacetylation regulation of apoptotic process regulation of cellular senescence Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3622 69260 Ensembl ENSG00000168556 ENSMUSG00000063049 UniProt Q9H160 Q9ESK4 RefSeq (mRNA) NM_001291959 NM_001564 NM_023503 RefSeq (protein) NP_001278888 NP_001555 NP_075992 Location (UCSC) Chr 4: 183.51 – 183.51 Mb Chr 8: 48.12 – 48.13 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.^[6]