ING4

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.^[5][6]

ING4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K1J, 2M1R, 2PNX, 2VNF, 4AFL
Identifiers
Aliases	ING4, my036, p29inhibitor of growth family member 4
External IDs	OMIM: 608524; MGI: 107307; HomoloGene: 22952; GeneCards: ING4; OMA:ING4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,650,301 bp[1] End 6,663,142 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 59.17 cM Start 125,016,723 bp[2] End 125,026,228 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence monocyte ventricular zone right hemisphere of cerebellum right uterine tube granulocyte right lobe of thyroid gland left lobe of thyroid gland C1 segment muscle layer of sigmoid colon Top expressed in granulocyte ventricular zone lip neural layer of retina thin ascending limb of loop of Henle right kidney spermatocyte muscle of thigh morula dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity metal ion binding methylated histone binding protein binding Cellular component histone acetyltransferase complex nucleus nucleoplasm cytosol intermediate filament cytoskeleton Biological process negative regulation of growth histone H4-K5 acetylation DNA replication histone acetylation histone H3 acetylation positive regulation of apoptotic process histone H4-K16 acetylation cell cycle negative regulation of transcription, DNA-templated histone H4-K8 acetylation histone H4-K12 acetylation negative regulation of cell population proliferation protein acetylation DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator apoptotic process chromatin organization positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51147 28019 Ensembl ENSG00000111653 ENSMUSG00000030330 UniProt Q9UNL4 Q8C0D7 RefSeq (mRNA) NM_001127582 NM_001127583 NM_001127584 NM_001127585 NM_001127586 NM_016162 NM_198287 NM_133345 NM_144510 NM_001368695 RefSeq (protein) NP_001121054 NP_001121055 NP_001121056 NP_001121057 NP_001121058 NP_057246 NP_579923 NP_001355624 Location (UCSC) Chr 12: 6.65 – 6.66 Mb Chr 6: 125.02 – 125.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.^[6]

Interactions

ING4 has been shown to interact with EP300,^[5] RELA^[7] and P53.^[5][8]