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ING4

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

ING4
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Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.[5][6]

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Function

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.[6]

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Interactions

ING4 has been shown to interact with EP300,[5] RELA[7] and P53.[5][8]

References

Further reading

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