ING5

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.^[5][6]

ING5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C6W
Identifiers
Aliases	ING5, p28inhibitor of growth family member 5
External IDs	OMIM: 608525; MGI: 1922816; HomoloGene: 90955; GeneCards: ING5; OMA:ING5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 241,687,085 bp[1] End 241,729,478 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 93,731,687 bp[2] End 93,749,823 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right uterine tube left ovary right hemisphere of cerebellum body of pancreas right lobe of thyroid gland left lobe of thyroid gland right ovary pituitary gland anterior pituitary Top expressed in primitive streak medullary collecting duct otic vesicle otolith organ hand utricle cumulus cell retinal pigment epithelium ciliary body epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function methylated histone binding protein binding metal ion binding chromatin binding Cellular component MOZ/MORF histone acetyltransferase complex nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated DNA replication negative regulation of growth regulation of transcription, DNA-templated histone acetylation histone H3 acetylation transcription, DNA-templated protein acetylation negative regulation of cell population proliferation positive regulation of apoptotic process regulation of signal transduction by p53 class mediator chromatin organization positive regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84289 66262 Ensembl ENSG00000168395 ENSMUSG00000026283 UniProt Q8WYH8 Q9D8Y8 RefSeq (mRNA) NM_032329 NM_001330161 NM_001330162 NM_025454 NM_029340 RefSeq (protein) NP_001317090 NP_001317091 NP_115705 NP_079730 Location (UCSC) Chr 2: 241.69 – 241.73 Mb Chr 1: 93.73 – 93.75 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.^[6]

Interactions

ING5 has been shown to interact with EP300^[5] and P53.^[5]