INHBC

Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene.^[5][6]

INHBC
Identifiers
Aliases	INHBC, IHBC, inhibin beta C, inhibin beta C subunit, inhibin subunit beta C
External IDs	OMIM: 601233; MGI: 105932; HomoloGene: 21142; GeneCards: INHBC; OMA:INHBC - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,434,784 bp[1] End 57,452,062 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 74.5 cM Start 127,192,191 bp[2] End 127,206,300 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle tibialis anterior muscle pancreatic ductal cell mucosa of ileum deltoid muscle skin of thigh cerebellum cerebellar cortex right hemisphere of cerebellum Top expressed in liver yolk sac embryo embryo placenta islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function growth factor activity transforming growth factor beta receptor binding hormone activity cytokine activity Cellular component extracellular region extracellular space Biological process positive regulation of pathway-restricted SMAD protein phosphorylation regulation of MAPK cascade cell development regulation of apoptotic process SMAD protein signal transduction regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3626 16325 Ensembl ENSG00000175189 ENSMUSG00000025405 UniProt P55103 P55104 RefSeq (mRNA) NM_005538 NM_010565 RefSeq (protein) NP_005529 NP_034695 Location (UCSC) Chr 12: 57.43 – 57.45 Mb Chr 10: 127.19 – 127.21 Mb PubMed search [3] [4]
Wikidata
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This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.^[6]