INO80B (gene)

INO80 complex subunit B is a protein that in humans is encoded by the INO80B gene. ^[5]

INO80 stabilizes replication forks and counteracts mislocalization of H2A.Z

INO80B
Identifiers
Aliases	INO80B, HMGA1L4, HMGIYL4, IES2, PAP-1BP, PAPA-1, ZNHIT4, hIes2, PAPA1, INO80 complex subunit B
External IDs	OMIM: 616456; MGI: 1917270; HomoloGene: 32566; GeneCards: INO80B; OMA:INO80B - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.1 Start 74,455,087 bp[1] End 74,457,944 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 83,098,746 bp[2] End 83,102,412 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right uterine tube left ovary pituitary gland fundus anterior pituitary thyroid gland left lobe of thyroid gland right ovary skin of abdomen Top expressed in internal carotid artery external carotid artery interventricular septum granulocyte ventricular zone seminiferous tubule muscle of thigh epiblast left lobe of liver lip More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding Cellular component nucleus Ino80 complex nucleoplasm nucleolus Biological process chromatin remodeling DNA recombination regulation of transcription, DNA-templated DNA repair transcription, DNA-templated cellular response to DNA damage stimulus protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83444 70020 Ensembl ENSG00000115274 ENSMUSG00000030034 UniProt Q9C086 Q99PT3 RefSeq (mRNA) NM_031288 NM_023547 RefSeq (protein) NP_112578 NP_076036 Location (UCSC) Chr 2: 74.46 – 74.46 Mb Chr 6: 83.1 – 83.1 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript.