INPP1

Inositol polyphosphate 1-phosphatase is an enzyme that, in humans, is encoded by the INPP1 gene.^[5][6] INPP1 encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.^[6]

INPP1
Identifiers
Aliases	INPP1, inositol polyphosphate-1-phosphatase
External IDs	OMIM: 147263; MGI: 104848; HomoloGene: 1655; GeneCards: INPP1; OMA:INPP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.2 Start 190,343,570 bp[1] End 190,371,665 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C1.1|1 26.99 cM Start 52,824,586 bp[2] End 52,856,847 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm corpus callosum middle frontal gyrus mucosa of pharynx cervix epithelium inferior ganglion of vagus nerve left testis epithelium of nasopharynx right testis duodenum Top expressed in granulocyte neural layer of retina cerebellar cortex thymus dentate gyrus of hippocampal formation granule cell spermatid seminal vesicula superior frontal gyrus lobe of cerebellum seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inositol-1,4-bisphosphate 1-phosphatase activity inositol-1,3,4-trisphosphate 1-phosphatase activity hydrolase activity metal ion binding protein binding Cellular component cytosol Biological process phosphate-containing compound metabolic process phosphatidylinositol phosphate biosynthetic process inositol phosphate metabolic process signal transduction dephosphorylation inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3628 16329 Ensembl ENSG00000151689 ENSMUSG00000026102 UniProt P49441 P49442 RefSeq (mRNA) NM_001128928 NM_002194 NM_008384 RefSeq (protein) NP_001122400 NP_002185 NP_032410 Location (UCSC) Chr 2: 190.34 – 190.37 Mb Chr 1: 52.82 – 52.86 Mb PubMed search [3] [4]
Wikidata
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