INPP4A

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.^[5][6][7]

INPP4A
Identifiers
Aliases	INPP4A, INPP4, TVAS1, inositol polyphosphate-4-phosphatase type I A
External IDs	OMIM: 600916; MGI: 1931123; HomoloGene: 2871; GeneCards: INPP4A; OMA:INPP4A - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 98,444,854 bp[1] End 98,594,392 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 B|1 15.46 cM Start 37,338,946 bp[2] End 37,449,817 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell tibia entorhinal cortex postcentral gyrus superior frontal gyrus buccal mucosa cell middle temporal gyrus lateral nuclear group of thalamus visceral pleura Top expressed in perirhinal cortex entorhinal cortex CA3 field trigeminal ganglion primary visual cortex superior frontal gyrus granulocyte dentate gyrus of hippocampal formation granule cell cerebellar cortex Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity protein binding hydrolase activity inositol-3,4-bisphosphate 4-phosphatase activity phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity inositol-1,3,4-trisphosphate 4-phosphatase activity Cellular component cytosol cytoplasm Biological process phosphatidylinositol biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process inositol phosphate metabolic process signal transduction dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3631 269180 Ensembl ENSG00000040933 ENSMUSG00000026113 UniProt Q96PE3 Q9EPW0 RefSeq (mRNA) NM_001134224 NM_001134225 NM_001566 NM_004027 NM_001351424 NM_001351425 NM_001351426 NM_001351427 NM_001351428 NM_001351429 NM_001290797 NM_001290798 NM_001290799 NM_030266 NM_172971 NM_001374629 NM_001374630 RefSeq (protein) NP_001127696 NP_001127697 NP_001557 NP_004018 NP_001338353 NP_001338354 NP_001338355 NP_001338356 NP_001338357 NP_001338358 NP_001277726 NP_001277727 NP_001277728 NP_084542 NP_766559 NP_001361558 NP_001361559 Location (UCSC) Chr 2: 98.44 – 98.59 Mb Chr 1: 37.34 – 37.45 Mb PubMed search [3] [4]
Wikidata
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INPP4A encodes the inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate.^[7]