INPP5A

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.^[5][6]

INPP5A
Identifiers
Aliases	INPP5A, 5PTASE, inositol polyphosphate-5-phosphatase A
External IDs	OMIM: 600106; MGI: 2686961; HomoloGene: 4045; GeneCards: INPP5A; OMA:INPP5A - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 132,537,787 bp[1] End 132,783,480 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 138,969,025 bp[2] End 139,159,568 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus saphenous vein myocardium of left ventricle middle temporal gyrus popliteal artery tibial arteries sperm external globus pallidus right ventricle gastric mucosa Top expressed in Ileal epithelium cardiac muscle tissue of left ventricle lobe of cerebellum right ventricle cerebellar vermis interventricular septum plantaris muscle ascending aorta extensor digitorum longus muscle soleus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PH domain binding inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity protein binding hydrolase activity inositol-1,4,5-trisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity Cellular component plasma membrane membrane intracellular anatomical structure Biological process inositol phosphate metabolic process phosphatidylinositol dephosphorylation inositol phosphate-mediated signaling inositol phosphate dephosphorylation dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3632 212111 Ensembl ENSG00000068383 ENSMUSG00000025477 UniProt Q14642 Q5T1B3 Q7TNC9 RefSeq (mRNA) NM_005539 NM_001321042 NM_001127363 NM_183144 NM_001355162 RefSeq (protein) NP_001307971 NP_005530 NP_001120835 NP_001342091 NP_898967 Location (UCSC) Chr 10: 132.54 – 132.78 Mb Chr 7: 138.97 – 139.16 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins (1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.^[6]