INSL3

Insulin-like 3 is a protein that in humans is encoded by the INSL3 gene.^[5][6]

INSL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H8B, 2K6T, 2K6U
Identifiers
Aliases	INSL3, RLF, RLNL, ley-I-L, insulin like 3
External IDs	OMIM: 146738; MGI: 108427; HomoloGene: 4048; GeneCards: INSL3; OMA:INSL3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 17,816,512 bp[1] End 17,821,574 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.43 cM Start 72,141,858 bp[2] End 72,143,219 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis testicle gonad granulocyte buccal mucosa cell blood spleen appendix right ovary Top expressed in testicle spermatocyte spleen islet of Langerhans bone marrow urinary bladder adrenal gland duodenum thymus embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protease binding signaling receptor binding insulin receptor binding hormone activity G protein-coupled receptor binding Cellular component extracellular region extracellular space Biological process cell-cell signaling positive regulation of wound healing positive regulation of epithelial cell migration spermatogenesis regulation of signaling receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3640 16336 Ensembl ENSG00000248099 ENSMUSG00000079019 UniProt P51460 O09107 Q5RL10 RefSeq (mRNA) NM_005543 NM_001265587 NM_013564 RefSeq (protein) NP_001252516 NP_005534 NP_038592 Location (UCSC) Chr 19: 17.82 – 17.82 Mb Chr 8: 72.14 – 72.14 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. INSL-3 initiates meiotic progression in follicle-enclosed oocytes by mediating a reduction in intra-oocyte cAMP concentration by activating leucine-rich repeat-containing G protein-coupled receptor 8 (LGR8).^[7] It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism.^[6]