INSL5

Insulin-like peptide 5 (INSL5) is a protein that in humans is encoded by the INSL5 gene.^[5][6]

INSL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K1V, 2KBC
Identifiers
Aliases	INSL5, PRO182, UNQ156, insulin like 5
External IDs	OMIM: 606413; MGI: 1346085; HomoloGene: 48350; GeneCards: INSL5; OMA:INSL5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 66,797,740 bp[1] End 66,801,276 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C6|4 47.27 cM Start 102,875,069 bp[2] End 102,884,039 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum mucosa of sigmoid colon testicle mucosa of transverse colon right uterine tube hypothalamus Brodmann area 9 nucleus accumbens hippocampus proper muscle tissue Top expressed in left colon neural layer of retina epithelium of small intestine thymus embryo embryo spermatid inner nuclear layer enteric nervous system outer nuclear layer More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hormone activity G protein-coupled receptor binding Cellular component extracellular region cellular component Biological process positive regulation of feeding behavior regulation of signaling receptor activity G protein-coupled receptor signaling pathway biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10022 23919 Ensembl ENSG00000172410 ENSMUSG00000066090 UniProt Q9Y5Q6 Q9WUG6 RefSeq (mRNA) NM_005478 NM_001290648 NM_011831 RefSeq (protein) NP_005469 NP_001277577 NP_035961 Location (UCSC) Chr 1: 66.8 – 66.8 Mb Chr 4: 102.88 – 102.88 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7).^[6]